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DNA repair/chromatin remodeling in cancer


Two teams, among the groups working on cancer at IPBS, investigate DNA transactions in pathological (ionizing radiations and clastogenic chemotherapeutic drugs) and physiological settings (antigen receptor rearrangements). Their respective projects highly benefit from collaborations with other IPBS teams specialized in NMR, structural biology and computer simulation, and from in-house core facilities such as proteomics, advanced light microscopy (two-photon microscopy), and animal facilities. 
In order to strengthen this research topic at IPBS, we are looking for a junior group leader using cutting-edge approaches in the DNA damage response (DDR) area, connected with cancer through epigenetics, transcriptional regulation, DNA repair pathologies, chromosomal translocations, DDR-based drug discovery, or tumor resistance to clastogenic agents. 


Selected publications from our research teams

  • Braikia et al. (2017) An inducible CTCF insulator delays the IgH 3’ regulatory region-mediated activation of germline promoters and alters class switching. PNAS
  • Chanut, Britton et al. (2016) Coordinated nuclease activities release Ku from single-ended DNA double strand breaks. Nat Commun
  • Menchon et al. (2016) Structure-based virtual ligand screening on the XRCC4/DNA ligase IV interface. Sci Rep
  • Britton, Dernoncourt et al. (2014) DNA damage triggers SAF-A and RNA biogenesis factors exclusion from chromatin coupled to R-loops removal. Nucleic Acids Res 
  • Yuan, Britton et al. (2015) Single-stranded DNA oligomers stimulate error-prone alternative repair of DNA double-strand breaks through hijacking Ku protein. Nucleic Acids Res
  • Braikia et al. (2015) Developmental switch in the transcriptional activity of a long-range regulatory element. Mol Cell Biol
  • Puget et al. (2015) Insertion of an imprinted insulator into the IgH locus reveals developmentally regulated, transcription-dependent control of V(D)J recombination. Mol Cell Biol
  • Cottarel et al. (2013) A noncatalytic function of the ligation complex during nonhomologous end joining. J Cell Biol
  • Haddad et al. (2011) Sense transcription through the S region is essential for immunoglobulin class switch recombination. EMBO J
  • Cheng et al. (2011) Ku counteracts mobilization of PARP1 and MRN in chromatin damaged with DNA double-strand breaks. Nucleic Acids Res
  • Bombarde et al. (2010) TRF2/RAP1 and DNA-PK mediate a double protection against joining at telomeric ends. EMBO J