On December 7th, Alexandre Gouzy will receive the Sanofi 2014 Prize from the Toulouse Academy of Sciences in recognition of his thesis work on nitrogen metabolism in Mycobacterium tuberculosis, the agent of tuberculosis in human.
Tuberculosis is still responsible for 1.3 million deaths each year on the global level. A. Gouzy’s thesis work, supported by the French Ministry of Higher Education and Research and by the Fondation pour la Recherche Médicale (FRM), led to a better understanding of how M. tuberculosis parasitizes immune cells, namely the macrophages, through utilizing aspartate and asparagine, two amino acids, for both nitrogen acquisition and resistance to acid stress in macrophages. Furthermore, this work allowed the identification of potential drug targets for novel anti-tuberculouse drugs.
Thanks to a fellowship from the FRM, A. Gouzy is now a post-doctoral fellow at the Weill Cornell Medical College in New York, where he pursues his research work on tuberculosis.
Gouzy A et al. (2013) Mycobacterium tuberculosis nitrogen assimilation and host colonization require aspartate. Nat Chem Biol 9:674-6
Gouzy et al. (2014) Mycobacterium tuberculosis exploits asparagine to assimilate nitrogen and resist acid stress during infection. PLOS Pathog 10:e1003928
Gouzy et al. (2014) The role of central nitrogen metabolism in Mycobacterium tuberculosis pathogenesis. Nat Rev Microbiol doi: 10.1038/nrmicro3349